Difference between revisions of "Two-component systems"
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Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a [[transcription factors|transcription factor]]). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. | Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a [[transcription factors|transcription factor]]). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. | ||
| − | More complex signal transduction systems of this class are called phosphorelay. The paradigm for a phosphorelay is the pathway leading to the phosphorylation of [[Spo0A]]. | + | More complex signal transduction systems of this class are called [[phosphorelay]]. The paradigm for a [[phosphorelay]] is the pathway leading to the phosphorylation of [[Spo0A]]. |
==Two-component systems in ''B. subtilis'' (kinase, regulator)== | ==Two-component systems in ''B. subtilis'' (kinase, regulator)== | ||
| Line 19: | Line 19: | ||
** [[NatK]], [[NatR]] | ** [[NatK]], [[NatR]] | ||
** [[PhoR]], [[PhoP]] | ** [[PhoR]], [[PhoP]] | ||
| + | ** [[PsdS]], [[PsdR]] | ||
** [[ResE]], [[ResD]] | ** [[ResE]], [[ResD]] | ||
** [[WalK]], [[WalR]]: the only essential two-component system! | ** [[WalK]], [[WalR]]: the only essential two-component system! | ||
| Line 25: | Line 26: | ||
** [[YclK]], [[YclJ]] | ** [[YclK]], [[YclJ]] | ||
** [[YkoH]], [[YkoG]] | ** [[YkoH]], [[YkoG]] | ||
| − | ** [[ | + | ** [[YrkQ]], [[YrkP]] |
| − | |||
** [[YvrG]], [[YvrHb]] | ** [[YvrG]], [[YvrHb]] | ||
** [[YxdK]], [[YxdJ]] | ** [[YxdK]], [[YxdJ]] | ||
| Line 42: | Line 42: | ||
** [[LytS]], [[LytT]] | ** [[LytS]], [[LytT]] | ||
** [[YesM]], [[YesN]] | ** [[YesM]], [[YesN]] | ||
| − | ** [[YwpD]] (orphan) | + | ** [[YwpD]] (orphan kinase) |
| − | ==The phosphorelay== | + | * Orphan response regulator |
| + | ** [[YneI]] | ||
| + | |||
| + | ==The [[phosphorelay]]== | ||
* Kinases | * Kinases | ||
** [[KinA]] | ** [[KinA]] | ||
| Line 52: | Line 55: | ||
** [[KinE]] | ** [[KinE]] | ||
| − | * | + | * Phosphotransferases |
** [[Spo0F]] | ** [[Spo0F]] | ||
** [[Spo0B]] | ** [[Spo0B]] | ||
| Line 58: | Line 61: | ||
* The ultimate target | * The ultimate target | ||
** [[Spo0A]] | ** [[Spo0A]] | ||
| + | |||
| + | ==Related lists== | ||
| + | * [[phosphorelay]] | ||
| + | * [[response regulator aspartate phosphatases]] | ||
| + | * [[phosphoproteins]] | ||
| + | * [[protein kinases and phosphatases]] | ||
| + | |||
| + | ==Important original publications== | ||
| + | <pubmed>21665979</pubmed> | ||
==Reviews== | ==Reviews== | ||
| − | <pubmed>17338439 19575571 | + | <pubmed>17338439 19575571 17158704 17433693 17913492 18832064 19943903 20117042 18076326 20080056 20133181 20133179 21051349 23279101 23352354 22746333 24494032 27519796</pubmed> |
| + | '''Reviews that appeared before 2005''': {{PubMed|11406410,10966457,10932244,10094672,11489844,10745001,1664534}} | ||
Latest revision as of 08:05, 25 August 2016
Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a transcription factor). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. More complex signal transduction systems of this class are called phosphorelay. The paradigm for a phosphorelay is the pathway leading to the phosphorylation of Spo0A.
Contents
Two-component systems in B. subtilis (kinase, regulator)
- NarL-family
- OmpR family
- Orphan response regulator
The phosphorelay
- The ultimate target
Related lists
- phosphorelay
- response regulator aspartate phosphatases
- phosphoproteins
- protein kinases and phosphatases
Important original publications
Sebastian Dintner, Anna Staron, Evi Berchtold, Tobias Petri, Thorsten Mascher, Susanne Gebhard
Coevolution of ABC transporters and two-component regulatory systems as resistance modules against antimicrobial peptides in Firmicutes Bacteria.
J Bacteriol: 2011, 193(15);3851-62
[PubMed:21665979]
[WorldCat.org]
[DOI]
(I p)
Reviews
Reviews that appeared before 2005: PubMed
