lnrJ

lnrJ
168

two-component sensor kinase, involved in resistance to linearmycin

Locus
BSU_08290
Molecular weight
44.38 kDa
Isoelectric point
6.39
Protein length
400 aaSequenceBlast
Gene length
1203 bpSequenceBlast
Function
involved in resistance to linearmycin
Product
two-component sensor kinase
Essential
no
Synonyms
lnrJ, yfiJ
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4585 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
903,811  905,013
The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of LnrK
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
Domains
5 transmembrane segments
Histidine kinase domain (aa 190-385) (according to UniProt)
Structure
4GT8 (PDB) (from Staphylococcus aureus, corresponds to aa 259 ... 390, 31% identity)
P94438 (AlphaFold)
Modification
autophosphorylation on a His residue
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
lnrJ-lnrK
Description
PubMed
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lnrJ→lnrK

2025-03-17 20:11:57

ghost

77

3b2b211fdc6c1d8b24be84dbf8fea053f5e2ae75

2539EB691EC0C9828A8B7F8DE3013CDBCEF4A1D3

Biological materials
Mutant
BKE08290 (lnrJ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACGCTCATCACTCCCGATA,  downstream forward: _UP4_GTGCAGCAAAAGGAGAGTTT
BKK08290 (lnrJ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACGCTCATCACTCCCGATA,  downstream forward: _UP4_GTGCAGCAAAAGGAGAGTTT
References
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03AEADB134F1CAD8BBB3E1F625D597EBA1FDA30B

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Time of last update: 2025-04-02 13:29:39

Author of last update: Jstuelk