Difference between revisions of "Two-component systems"
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Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a [[transcription factors|transcription factor]]). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. | Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a [[transcription factors|transcription factor]]). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. | ||
More complex signal transduction systems of this class are called [[phosphorelay]]. The paradigm for a [[phosphorelay]] is the pathway leading to the phosphorylation of [[Spo0A]]. | More complex signal transduction systems of this class are called [[phosphorelay]]. The paradigm for a [[phosphorelay]] is the pathway leading to the phosphorylation of [[Spo0A]]. | ||
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==Reviews== | ==Reviews== | ||
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Revision as of 09:34, 24 November 2010
Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a transcription factor). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. More complex signal transduction systems of this class are called phosphorelay. The paradigm for a phosphorelay is the pathway leading to the phosphorylation of Spo0A.
Contents
Two-component systems in B. subtilis (kinase, regulator)
- NarL-family
- OmpR family
- Orphan response regulator
The phosphorelay
- The ultimate target
Related lists
- phosphorelay
- response regulator aspartate phosphatases
- phosphoproteins
- protein kinases and phosphatases
Reviews
