SigD regulon

Regulator	SigD
Overview on the regulons (wiki page) Overview on the regulons (Excel file)

Genes in this regulon

• as-gdpP
• cheV
• cwlQ
• cwlS
• degR
• dltA
• dltB
• dltC
• dltD
• dltE
• epr
• flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-flgD-flgE-fliL-fliM-fliY-cheY-fliZ-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
• flgK
• flgL
• flgM
• flhO
• flhP
• fliD
• fliS
• fliT
• hag
• hemAT
• lytA
• lytB
• lytC
• lytD
• lytF
• mcpA
• mcpB
• mcpC
• motA
• motB
• nfrA
• pgdS
• sigA
• tlpA
• tlpB
• tlpC
• ybdO
• yfmS
• yfmT
• yjcP
• yjcQ
• yjfB
• ylqB
• yoaH
• yscB
• yvyC
• yvyF
• yvyG
• ywcH
• yxkC

Comments

• • the SigD regulon is strongly overexpressed in a ymdB mutant (loss of bistable gene expression) PubMed
  • expression of the SigD regulon is reduced upon overexpression of SlrA, this can be suppressed by mutations in remA, remB, sinR, or slrR PubMed

Important publications on the SigD regulon

Loralyn M Cozy, Andrew M Phillips, Rebecca A Calvo, Ashley R Bate, Yi-Huang Hsueh, Richard Bonneau, Patrick Eichenberger, Daniel B Kearns
SlrA/SinR/SlrR inhibits motility gene expression upstream of a hypersensitive and hysteretic switch at the level of σ(D) in Bacillus subtilis.
Mol Microbiol: 2012, 83(6);1210-28
[PubMed:22329926] [WorldCat.org] [DOI] (I p)

Diethmaier C, Pietack N, Gunka K, Wrede C, Lehnik-Habrink M, Herzberg C, Hübner S, Stülke J  
A Novel Factor Controlling Bistability in Bacillus subtilis: The YmdB Protein Affects
Flagellin Expression and Biofilm Formation. 
J Bacteriol.: 2011, 193(21):5997-6007. 
PubMed:21856853

Masakuni Serizawa, Hiroki Yamamoto, Hirotake Yamaguchi, Yasutaro Fujita, Kazuo Kobayashi, Naotake Ogasawara, Junichi Sekiguchi
Systematic analysis of SigD-regulated genes in Bacillus subtilis by DNA microarray and Northern blotting analyses.
Gene: 2004, 329;125-36
[PubMed:15033535] [WorldCat.org] [DOI] (P p)

L M Márquez, J D Helmann, E Ferrari, H M Parker, G W Ordal, M J Chamberlin
Studies of sigma D-dependent functions in Bacillus subtilis.
J Bacteriol: 1990, 172(6);3435-43
[PubMed:2111808] [WorldCat.org] [DOI] (P p)