SigD regulon

Regulator	SigD
Overview on the regulons (wiki page) Overview on the regulons (Excel file)

Genes in this regulon

• as-gdpP
• cheV
• cwlQ
• cwlS
• degR
• dltA
• dltB
• dltC
• dltD
• dltE
• epr
• flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-flgD-flgE-fliL-fliM-fliY-cheY-fliZ-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
• flgK
• flgL
• flgM
• flgN
• flhO
• flhP
• fliD
• fliS
• fliT
• hag
• hemAT
• lytA
• lytB
• lytC
• lytD
• lytF
• mcpA
• mcpB
• mcpC
• motA
• motB
• nfrA
• pgdS
• rnaC
• sigA
• sivC
• swrAA-minJ
• tlpA
• tlpB
• tlpC
• ybdO
• yfmS
• yfmT
• yjcP
• yjcQ
• yjfB

• yoaH
• yscB
• yvyC
• yvyF

• ywcH
• yxkC

newly added

• yabN-yabO
• yjcM
• xkdA
• dgcW
• rnhB-ylqG-ylqH
• ylzI
• yoyG
• cgeD-cgeE
• yqaR
• yqaS
• ytlR
• yvaQ
• yvbI
• fliW
• smiA
• csrA
• yviE
• yxkH

Comments

• the SigD regulon is strongly overexpressed in a ymdB mutant (loss of bistable gene expression) PubMed
• expression of the SigD regulon is reduced upon overexpression of SlrA, this can be suppressed by mutations in remA, remB, sinR, or slrR PubMed
• expression of the SigD regulon is reduced in pnpA mutants due to reduced sigD expression PubMed
• the SigD regulon is not expressed in a rpsU mutant, this can be suppressed by inactivation of remA PubMed

Important publications on the SigD regulon

Mario L Arrieta-Ortiz, Christoph Hafemeister, Ashley Rose Bate, Timothy Chu, Alex Greenfield, Bentley Shuster, Samantha N Barry, Matthew Gallitto, Brian Liu, Thadeous Kacmarczyk, Francis Santoriello, Jie Chen, Christopher D A Rodrigues, Tsutomu Sato, David Z Rudner, Adam Driks, Richard Bonneau, Patrick Eichenberger
An experimentally supported model of the Bacillus subtilis global transcriptional regulatory network.
Mol Syst Biol: 2015, 11(11);839
[PubMed:26577401] [WorldCat.org] [DOI] (I e)

Hiraku Takada, Masato Morita, Yuh Shiwa, Ryoma Sugimoto, Shota Suzuki, Fujio Kawamura, Hirofumi Yoshikawa
Cell motility and biofilm formation in Bacillus subtilis are affected by the ribosomal proteins, S11 and S21.
Biosci Biotechnol Biochem: 2014, 78(5);898-907
[PubMed:25035996] [WorldCat.org] [DOI] (I p)

Loralyn M Cozy, Andrew M Phillips, Rebecca A Calvo, Ashley R Bate, Yi-Huang Hsueh, Richard Bonneau, Patrick Eichenberger, Daniel B Kearns
SlrA/SinR/SlrR inhibits motility gene expression upstream of a hypersensitive and hysteretic switch at the level of σ(D) in Bacillus subtilis.
Mol Microbiol: 2012, 83(6);1210-28
[PubMed:22329926] [WorldCat.org] [DOI] (I p)

Christine Diethmaier, Nico Pietack, Katrin Gunka, Christoph Wrede, Martin Lehnik-Habrink, Christina Herzberg, Sebastian Hübner, Jörg Stülke
A novel factor controlling bistability in Bacillus subtilis: the YmdB protein affects flagellin expression and biofilm formation.
J Bacteriol: 2011, 193(21);5997-6007
[PubMed:21856853] [WorldCat.org] [DOI] (I p)

Masakuni Serizawa, Hiroki Yamamoto, Hirotake Yamaguchi, Yasutaro Fujita, Kazuo Kobayashi, Naotake Ogasawara, Junichi Sekiguchi
Systematic analysis of SigD-regulated genes in Bacillus subtilis by DNA microarray and Northern blotting analyses.
Gene: 2004, 329;125-36
[PubMed:15033535] [WorldCat.org] [DOI] (P p)

L M Márquez, J D Helmann, E Ferrari, H M Parker, G W Ordal, M J Chamberlin
Studies of sigma D-dependent functions in Bacillus subtilis.
J Bacteriol: 1990, 172(6);3435-43
[PubMed:2111808] [WorldCat.org] [DOI] (P p)