CodV

• Description: site-specific integrase/recombinase
  
  

Gene name	codV
Synonyms
Essential	no
Product	site-specific integrase/recombinase
Function	chromosome partitioning
Gene expression levels in SubtiExpress: codV
MW, pI	35 kDa, 9.31
Gene length, protein length	912 bp, 304 aa
Immediate neighbours	trmFO, clpQ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA condensation/ segregation

This gene is a member of the following regulons

CodY regulon

The gene

Basic information

• Locus tag: BSU16140

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: resolution of chromosome dimers by site specific recombination at the dif site (located close to the terminus region on the chromosome)

• Protein family: XerC subfamily (according to Swiss-Prot)

• Paralogous protein(s): RipX

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)
  • assembles on the chromosome at the dif site throughout the cell cycle PubMed

Database entries

• Structure:

• UniProt: P39776

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: codV-clpQ-clpY-codY PubMed

• Expression browser: codV PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • CodY: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A794 ( codV::kan), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Xindan Wang, Paula Montero Llopis, David Z Rudner
Organization and segregation of bacterial chromosomes.
Nat Rev Genet: 2013, 14(3);191-203
[PubMed:23400100] [WorldCat.org] [DOI] (I p)