clpY

clpY
168

two-component ATP-dependent protease, ATPase subunit

Locus
BSU_16160
Molecular weight
52.42 kDa
Isoelectric point
5.31
Protein length
467 aaSequenceBlast
Gene length
1404 bpSequenceBlast
Function
protein degradation
Product
two-component ATP-dependent protease, ATPase subunit
Essential
no
Synonyms
clpY, hslU, codX
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1220 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,688,676  1,690,079
Phenotypes of a mutant
impaired in swarming motility PubMed
The protein
Protein family
ClpX chaperone family (with ClpX, according to UniProt)
Structure
1DO2 (PDB) (from E. coli, 51% identity) PubMed
P39778 (AlphaFold)
Expression and Regulation
Operons
Genes
trmFO-codV-clpQ-clpY-codY
Description
PubMed
Regulation
repressed during growth in the presence of branched chain amino acids (CodY) PubMed
Regulatory mechanism
CodY: repression, PubMed, in codY regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Additional information
the intracellular concentration of CodY is about 2.5 myM (according to PubMed)
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trmFO→codY

2025-03-26 02:44:42

Jstuelk

125

14a27ac38158bfce7849c72f786e8673bc2ce6b1

5257B6B5AFCAE25607CF5DD2E50F759EF0225538

Biological materials
Mutant
BKE16160 (clpY::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCGCCTCAAGTCCTTTC,  downstream forward: _UP4_TGAAAAATTTAATATGAGGA
BKK16160 (clpY::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCGCCTCAAGTCCTTTC,  downstream forward: _UP4_TGAAAAATTTAATATGAGGA
References
Reviews
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Original Publications
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2A5A080273CB7698DFABB147F4143E90BBCA3B01

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Time of last update: 2025-04-03 03:47:42

Author of last update: Jstuelk