Difference between revisions of "ComS"

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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
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* overexpression of [[ComS]] results in expression of competence genes in 80% to 90% of the cells {{PubMed|8878039}}   
  
 
=== Database entries ===
 
=== Database entries ===
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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
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* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
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* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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==Original Publications==
 
==Original Publications==
<pubmed>17560370,10447896, 12642660,9000055, 10361283, 10447896, 11703662 1715856 16091051 20817675</pubmed>
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<pubmed>17560370,10447896, 12642660,9000055, 10361283, 10447896, 11703662 1715856 16091051 20817675 8878039</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 11:33, 16 March 2014

  • Description: antiadaptor protein, assembly link between regulatory components of the competence signal transduction pathway

Gene name comS
Synonyms
Essential no
Product antiadaptor protein (anti-MecA)
Function control of ComK degradation
Gene expression levels in SubtiExpress: comS
Interactions involving this protein in SubtInteract: ComS
MW, pI 5 kDa, 9.145
Gene length, protein length 138 bp, 46 aa
Immediate neighbours srfAB, srfAC
Sequences Protein DNA DNA_with_flanks
Genetic context
ComS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ComS expression.png















Categories containing this gene/protein

genetic competence, short peptides

This gene is a member of the following regulons

Abh regulon, CodY regulon, ComA regulon, PerR regulon, Spx regulon

The gene

Basic information

  • Locus tag: BSU03500

Phenotypes of a mutant

  • overexpression of ComS results in expression of competence genes in 80% to 90% of the cells PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
    • repressed during hydrogen peroxide stress (PerR) PubMed
    • expressed at high cell density (ComA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews


Original Publications