Difference between revisions of "RNA switch"

Revision as of 11:17, 26 April 2013

RNA switches are regulatory systems that rely on alternative mRNA structures.

RNA switches may be triggered by proteins, tRNAs (T-box), or metabolites (riboswitches)

Protein-dependent RNA switches
- L20 leader: in front of the infC-rpmI-rplT-ysdA operon: controlled by RplT binding
- S4 leader: in front of the rpsD gene: controlled by RpsD binding
- S15 leader: in front of the rpsO gene: controlled by RpsO binding
- ptsG-ptsH-ptsI: controlled by GlcT
- sacX-sacY, sacB: controlled by SacY
- sacP-sacA: controlled by SacT
- bglS, bglP-bglH-yxiE: controlled by LicT
- glpD, glpF-glpK, glpT-glpQ: controlled by GlpP
- pabA, trpE-trpD-trpC-trpF-trpB-trpA, trpP, ycbK: controlled by TRAP
- hutH-hutU-hutI-hutG-hutM: controlled by HutP
- pyrR-pyrP-pyrB-pyrC-pyrAA-pyrAB-pyrK-pyrD-pyrF-pyrE: controlled by PyrR

Metabolite-dependent RNA switches: Riboswitches
- A-box
- FMN-box
- G-box
- Gly-box
- L-box
- M-box
- preQ1 riboswitch
- ribozyme: glmS
- S-box
- Thi-box
- YdaO riboswitch

Additional RNA switches
- pyrG RNA switch: low levels of intracellular CTP induce reiterative addition of G residues at position +4 in the 5' end of the pyrG mRNA, which is encoded as pppGGGC. . . . The poly(G) sequences formed under these conditions act to prevent attenuation by base pairing with the C- and U-rich 5' strand of a downstream terminator stem-loop located in the pyrG leader. PubMed
- EAR (eps-associated RNA switch): located between epsB and epsC, mediates processive antitermination and allows expression of the long eps operon PubMed

The function of the following potential RNA structures is unknown. They were suggested to control the mentioned genes.

@@ Line 7: / Line 7: @@
 * '''Protein-dependent RNA switches'''
 ** [http://rfam.sanger.ac.uk/family?acc=RF00558 L20 leader]: in front of the ''[[infC]]-[[rpmI]]-[[rplT]]-[[ysdA]]'' operon: controlled by [[RplT]] binding
+** S4 leader: in front of the ''[[rpsD]]'' gene: controlled by ''RpsD'' binding
+** S15 leader: in front of the ''[[rpsO]]'' gene: controlled by ''RpsO'' binding
 ** ''[[ptsG]]-[[ptsH]]-[[ptsI]]'': controlled by [[GlcT]]
 ** ''[[sacX]]-[[sacY]]'', ''[[sacB]]'': controlled by [[SacY]]