Difference between revisions of "RNA switch"
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RNA switches may be triggered by proteins, tRNAs ([[T-box]]), or metabolites (riboswitches) | RNA switches may be triggered by proteins, tRNAs ([[T-box]]), or metabolites (riboswitches) | ||
| − | ==List of ''Bacillus subtilis'' | + | ==List of the ''Bacillus subtilis'' RNA switches== |
* '''Protein-dependent RNA switches''' | * '''Protein-dependent RNA switches''' | ||
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**[[YdaO riboswitch]] | **[[YdaO riboswitch]] | ||
| − | * ''' | + | * '''Additional RNA switches''' |
** ''[[pyrG]]'' RNA switch: low levels of intracellular CTP induce reiterative addition of G residues at position +4 in the 5' end of the ''[[pyrG]]'' mRNA, which is encoded as pppGGGC. . . . The poly(G) sequences formed under these conditions act to prevent attenuation by base pairing with the C- and U-rich 5' strand of a downstream terminator stem-loop located in the ''[[pyrG]]'' leader. {{PubMed|17302819}} | ** ''[[pyrG]]'' RNA switch: low levels of intracellular CTP induce reiterative addition of G residues at position +4 in the 5' end of the ''[[pyrG]]'' mRNA, which is encoded as pppGGGC. . . . The poly(G) sequences formed under these conditions act to prevent attenuation by base pairing with the C- and U-rich 5' strand of a downstream terminator stem-loop located in the ''[[pyrG]]'' leader. {{PubMed|17302819}} | ||
** EAR (eps-associated RNA switch): located between'' [[epsB]]'' and ''[[epsC]]'', mediates processive antitermination and allows expression of the long eps operon {{PubMed|20374491}} | ** EAR (eps-associated RNA switch): located between'' [[epsB]]'' and ''[[epsC]]'', mediates processive antitermination and allows expression of the long eps operon {{PubMed|20374491}} | ||
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** L19 leader: ''[[rplS]]'' | ** L19 leader: ''[[rplS]]'' | ||
** [http://rfam.sanger.ac.uk/family?acc=RF00559 L21_leader]:in front of the ''[[rplU]]-[[ysxB]]-[[rpmA]]'' operon | ** [http://rfam.sanger.ac.uk/family?acc=RF00559 L21_leader]:in front of the ''[[rplU]]-[[ysxB]]-[[rpmA]]'' operon | ||
| + | |||
| + | * RNA switch candidates {{PubMed|20525796}}, upstream of: | ||
| + | ** ''[[clpX]]'' | ||
| + | ** ''[[rpoB]]'' | ||
| + | ** ''[[pdhA]]'' | ||
| + | ** ''[[citZ]]'' | ||
| + | ** ''[[yybN]]'' | ||
| + | ** ''[[cwlO]]'' | ||
| + | ** ''[[yxjJ]]'' | ||
| + | ** ''[[ylxS]]'' | ||
| + | ** ''[[ycdA]]'' | ||
| + | ** ''[[tig]]'' | ||
| + | ** ''[[ydbN]]'' | ||
| + | ** ''[[rny]]'' | ||
| + | ** ''[[yhdT]]'' | ||
| + | ** ''[[ypfD]]'' | ||
| + | ** ''[[sodA]]'' | ||
| + | ** ''[[spoVS]]'' | ||
| + | ** ''[[ylbK]]'' | ||
| + | ** ''[[tagD]]'' | ||
| + | ** ''[[yybS]]'' | ||
| + | ** ''[[rplK]]'' | ||
| + | ** ''[[fbaA]]'' | ||
| + | ** ''[[dhbA]]'' | ||
| + | ** ''[[yuxN]]'' | ||
| + | ** ''[[rplU]]'' | ||
| + | ** ''[[rpmH]]'' | ||
| + | ** ''[[rex]]'' | ||
| + | ** ''[[pelC]]'' | ||
| + | ** ''[[yxbB]]'' | ||
| + | |||
==[http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb130_1.html An overview on the structural aspects]== | ==[http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb130_1.html An overview on the structural aspects]== | ||
==Important Reviews== | ==Important Reviews== | ||
| − | + | <pubmed>15063848 , 19385727 19250859 ,19141470 , 17092822, 17764952 ,17381303, 16226486 , 16153177 , 15750802, 14523920 18430893 12029388 19859665 19298181 20230605 20384681 12787499 14698618 21317561 21477128 21334966 20525796</pubmed> | |
| − | <pubmed>15063848 , 19385727 19250859 ,19141470 , 17092822, 17764952 ,17381303, 16226486 , 16153177 , 15750802, 14523920 18430893 12029388 19859665 19298181 20230605 20384681 12787499 14698618 21317561 21477128 21334966 </pubmed> | ||
Revision as of 20:17, 4 May 2011
RNA switches are regulatory systems that rely on alternative mRNA structures.
RNA switches may be triggered by proteins, tRNAs (T-box), or metabolites (riboswitches)
List of the Bacillus subtilis RNA switches
- Protein-dependent RNA switches
- L20 leader: in front of the infC-rpmI-rplT-ysdA operon: controlled by RplT binding
- ptsG-ptsH-ptsI: controlled by GlcT
- sacX-sacY, sacB: controlled by SacY
- sacP-sacA: controlled by SacT
- bglS, bglP-bglH-yxiE: controlled by LicT
- glpD, glpF-glpK, glpT-glpQ: controlled by GlpP
- pabA, trpE-trpD-trpC-trpF-trpB-trpA, trpP, ycbK: controlled by TRAP
- hutH-hutU-hutI-hutG-hutM: controlled by HutP
- pyrR-pyrP-pyrB-pyrC-pyrAA-pyrAB-pyrK-pyrD-pyrF-pyrE: controlled by PyrR
- tRNA-dependent RNA switches: T-box
- Metabolite-dependent RNA switches: Riboswitches
- Additional RNA switches
- pyrG RNA switch: low levels of intracellular CTP induce reiterative addition of G residues at position +4 in the 5' end of the pyrG mRNA, which is encoded as pppGGGC. . . . The poly(G) sequences formed under these conditions act to prevent attenuation by base pairing with the C- and U-rich 5' strand of a downstream terminator stem-loop located in the pyrG leader. PubMed
- EAR (eps-associated RNA switch): located between epsB and epsC, mediates processive antitermination and allows expression of the long eps operon PubMed
The function of the following potential RNA structures is unknown. They were suggested to control the mentioned genes.
- yjdF switch: yjdF PubMed
- ykkC-yxkD switch: ykkC, yxkD
- yybP-ykoY switch: yybP, ykoY
- ylbH switch: ylbH
- L10 leader: rplJ
- L13 leader: rplM
- L19 leader: rplS
- L21_leader:in front of the rplU-ysxB-rpmA operon
- RNA switch candidates PubMed, upstream of:
An overview on the structural aspects
Important Reviews
