Difference between revisions of "FlhG"

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(→‎Extended information on the protein)
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* '''Description:''' swarming motility protein <br/><br/>
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* '''Description:''' GTPase activating protein, activates [[FlhF]] <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"| '''Product''' || swarming motility protein  
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|style="background:#ABCDEF;" align="center"| '''Product''' || GTPase activating protein  
 
|-
 
|-
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|style="background:#ABCDEF;" align="center"|'''Function''' || self-resistance to surfactin and swarming motility
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|style="background:#ABCDEF;" align="center"|'''Function''' || activation of [[FlhF]]
 +
|-
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/YlxH YlxH]
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 33 kDa, 9.648   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 33 kDa, 9.648   
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
  
−
susceptible to acriflavine and ethidium bromide, and severe growth inhibition as surfactin concentration increased up to 100ug/ml.
+
* susceptible to acriflavine and ethidium bromide, and severe growth inhibition as surfactin concentration increased up to 100ug/ml.
  
 
=== Database entries ===
 
=== Database entries ===
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=== Additional information===
 
=== Additional information===
−
 
−
 
  
  
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=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
−
* '''Catalyzed reaction/ biological activity:'''  
+
* '''Catalyzed reaction/ biological activity:''' binds [[FlhF]] and stimulates its GTPase activity {{PubMed|22056770}}
  
 
* '''Protein family:''' View classification (according to Swiss-Prot)
 
* '''Protein family:''' View classification (according to Swiss-Prot)
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* '''[[SubtInteract|Interactions]]:'''  
 
* '''[[SubtInteract|Interactions]]:'''  
 +
** [[YlxH]]-[[FlhF]] ([[YlxH]] binds the GTP-bound homodimer of [[FlhF]]) {{PubMed|22056770}}
  
−
* '''[[Localization]]:''' Cytoplasm (Homogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
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* '''[[Localization]]:''' cytoplasm (Homogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
  
 
=== Database entries ===
 
=== Database entries ===
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* '''Structure:'''
 
* '''Structure:'''
  
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* '''UniProt:''' [http://www.uniprot.org/uniprot/P40742 P40742]
+
* '''UniProt:'''  
 +
** [http://www.uniprot.org/uniprot/P40742 P40742]
 +
** [http://www.rcsb.org/pdb/explore.do?structureId=3SYN 3SYN] (complex with [[FlhF]]) {{PubMed|22056770}}
  
 
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU16410]
 
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU16410]
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=References=
 
=References=
  
−
<pubmed>15066026,17850253,14651647, 16479537 9657996,8157612,15175317</pubmed>
+
<pubmed>15066026,17850253,14651647, 16479537 9657996,8157612,15175317 22056770 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 09:56, 8 November 2011

  • Description: GTPase activating protein, activates FlhF

Gene name ylxH
Synonyms
Essential no
Product GTPase activating protein
Function activation of FlhF
Interactions involving this protein in SubtInteract: YlxH
MW, pI 33 kDa, 9.648
Gene length, protein length 894 bp, 298 aa
Immediate neighbours flhF, cheB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YlxH context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

motility and chemotaxis, resistance against toxins/ antibiotics

This gene is a member of the following regulons

CodY regulon, SigD regulon, Spo0A regulon

The gene

Basic information

  • Locus tag: BSU16410

Phenotypes of a mutant

  • susceptible to acriflavine and ethidium bromide, and severe growth inhibition as surfactin concentration increased up to 100ug/ml.

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: binds FlhF and stimulates its GTPase activity PubMed
  • Protein family: View classification (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

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