Difference between revisions of "CodY"
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− | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_synthesis.html Lipid synthesis]''' | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/other_nitrogen_sources/index.html Alternative nitrogen sources], [http://subtiwiki.uni-goettingen.de/pathways/fatty_acid_synthesis.html Lipid synthesis]''' |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 28 kDa, 4.75 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 28 kDa, 4.75 |
Revision as of 11:05, 11 December 2010
- Description: regulation of a large regulon in response to branched-chain amino acid limitation
Gene name | codY |
Synonyms | |
Essential | no |
Product | transcriptional pleiotropic repressor |
Function | regulation of a large regulon in response to
branched-chain amino acid limitation to the presence of branched-chain amino acids |
Metabolic function and regulation of this protein in SubtiPathways: Alternative nitrogen sources, Lipid synthesis | |
MW, pI | 28 kDa, 4.75 |
Gene length, protein length | 777 bp, 259 aa |
Immediate neighbours | clpY, flgB |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
Categories containing this gene/protein
regulators of core metabolism, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU16170
Phenotypes of a mutant
No swarming motility on B medium. PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: codY family (according to Swiss-Prot)
- Paralogous protein(s):
Genes/ operons controlled by CodY
Extended information on the protein
- Kinetic information:
- Domains: contains a GAF domain (ligand binding domain)
- Modification: phosphorylation on Ser-215 PubMed
- Cofactor(s):
- Effectors of protein activity: GTP and branched chained amino acids (BCAA) increase the affinity of CodY for its DNA target sequences PubMed
- Interactions: active as dimer (according to PubMed)
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P39779
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
- the intracellular concentration of CodY is about 2.5 myM (according to PubMed)
Biological materials
- Mutant: GP566, available in Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Linc Sonenshein, Tufts University, Boston, MA, USA Homepage
Tony Wilkinson, York University, U.K. homepage
Oscar Kuipers, University of Groningen, The Netherlands Homepage
Your additional remarks
References
Reviews
Sabine Brantl, Andreas Licht
Characterisation of Bacillus subtilis transcriptional regulators involved in metabolic processes.
Curr Protein Pept Sci: 2010, 11(4);274-91
[PubMed:20408793]
[WorldCat.org]
[DOI]
(I p)
Abraham L Sonenshein
Control of key metabolic intersections in Bacillus subtilis.
Nat Rev Microbiol: 2007, 5(12);917-27
[PubMed:17982469]
[WorldCat.org]
[DOI]
(I p)
Abraham L Sonenshein
CodY, a global regulator of stationary phase and virulence in Gram-positive bacteria.
Curr Opin Microbiol: 2005, 8(2);203-7
[PubMed:15802253]
[WorldCat.org]
[DOI]
(P p)
Original Publications