GabT

• Description: gamma-aminobutyrate transaminase, general stress protein
  
  

Gene name	gabT
Synonyms	ycnG
Essential	no
Product	gamma-aminobutyrate transaminase
Function	utilization of gamma-amino butyric acid and synthesis of norspermidine
Gene expression levels in SubtiExpress: gabT
MW, pI	47 kDa, 5.304
Gene length, protein length	1308 bp, 436 aa
Immediate neighbours	gabR, gabD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of amino acids, miscellaneous metabolic pathways, biofilm formation

This gene is a member of the following regulons

GabR regulon

The gene

Basic information

• Locus tag: BSU03900

Phenotypes of a mutant

• • block in norspermidine production PubMed
  • impaired biofilm disassembly PubMed
  • growth defect in the presence of gamma-aminobutyrate PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate (according to Swiss-Prot)

• Protein family: class-III pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P94427

• KEGG entry: [3]

• E.C. number: 2.6.1.19

Expression and regulation

• Operon: gabT-gabD PubMed

• Expression browser: gabT PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed in the presence of gamma-butyric acid and pyridoxal 5'-phosphate (GabR) PubMed

• Regulatory mechanism:
  • GabR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Linc Sonenshein, Tufts University, Boston, MA, USA Homepage