gabD

gabD
168

succinate-semialdehyde dehydrogenase (NADP), general stress protein

Locus
BSU_03910
Molecular weight
50.10 kDa
Isoelectric point
4.76
Protein length
462 aaSequenceBlast
Gene length
1389 bpSequenceBlast
Function
utilization of gamma-amino butyric acid
Product
succinate-semialdehyde dehydrogenase (NADP)
Essential
no
Synonyms
gabD, ycnH
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1012 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
442,950  444,338
Phenotypes of a mutant
growth defect in the presence of gamma-aminobutyrate  PubMed
The protein
Catalyzed reaction/ biological activity
H2O + NADP+ + succinate semialdehyde --> 2 H+ + NADPH + succinate (according to UniProt)
Protein family
aldehyde dehydrogenase family (according to UniProt)
Structure
3RHH (PDB) (from from Bacillus halodurans C-125 complexed with NADP, 36% identity, 68% similarity)
P94428 (AlphaFold)
Paralogous protein(s)
YfmT, AldX, AldY, GbsA, PutC, YcbD, DhaS, RocA, IolA, YwdH
Expression and Regulation
Operons
Genes
gabD
Description
PubMed
Regulation
''gabD'': induced by stress (SigB) PubMed
Regulatory mechanism
GabR: activation, PubMed, in gabR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigB: sigma factor, PubMed, in sigB regulon
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gabD

2025-03-27 03:58:04

ghost

114

3a0a53baa6f2174a955534e2b8ea518fd527da6e

1DE87C14F04B6A836A6E076AE45BB40C9B60A561

Genes
gabT-gabD
Description
PubMed
Regulation
''gabD'': induced by stress (SigB) PubMed
Regulatory mechanism
GabR: activation, PubMed, in gabR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

gabT→gabD

2025-03-16 18:07:36

ghost

92

e3e4e1f1822033b4069ae3a9c7bc374af762e4a0

3807B263B7F7E1F259288EF64815902EECED7726

Biological materials
Mutant
MGNA-C015 (ycnH::erm), available at the NBRP B. subtilis, Japan
BKE03910 (gabD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTGAACATTCCTTTCT,  downstream forward: _UP4_TAAAAGAATGCACGCTCCTG
BKK03910 (gabD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTGAACATTCCTTTCT,  downstream forward: _UP4_TAAAAGAATGCACGCTCCTG
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab
Labs working on this gene/protein
Linc Sonenshein, Tufts University, Boston, MA, USA Homepage
References
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A0BEB92D54799956A4ADE106A1388E5710141069

Page visits: 7332

Time of last update: 2025-04-03 11:34:23

Author of last update: Jstuelk