UxaC

• Description: glucuronate isomerase (D-glucuronate, D-galacturonate)
  
  

Gene name	uxaC
Synonyms	yjmA
Essential	no
Product	glucuronate isomerase (D-glucuronate, D-galacturonate)
Function	hexuronate utilization
Gene expression levels in SubtiExpress: uxaC
MW, pI	54 kDa, 5.174
Gene length, protein length	1419 bp, 473 aa
Immediate neighbours	ndh, yjmB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

CcpA regulon, ExuR regulon

The gene

Basic information

• Locus tag: BSU12300

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: D-glucuronate = D-fructuronate (according to Swiss-Prot)

• Protein family: uronate isomerase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34808

• KEGG entry: [3]

• E.C. number: 5.3.1.12

Expression and regulation

• Operon: uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed

• Expression browser: uxaC PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (CcpA) PubMed1 PubMed2
  • induced by galacturonate (ExuR) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed1 PubMed2
  • ExuR: reanscription repression in the absence of inducer PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: