uxaA

uxaA
168

altronate hydrolase

Locus
BSU_12390
Molecular weight
54.75 kDa
Isoelectric point
5.78
Protein length
497 aaSequenceBlast
Gene length
1494 bpSequenceBlast
Function
hexuronate utilization
Product
altronate hydrolase
Essential
no
E.C.
4.2.1.7
Synonyms
uxaA, yjmJ
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2721 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,311,319 → 1,312,812
The protein
Catalyzed reaction/ biological activity
D-altronate --> 2-dehydro-3-deoxy-D-gluconate + H2O (according to UniProt)
Protein family
UxaA family (with YcbH, according to UniProt)
Structure
6U7L (PDB) (from E. coli, 34% identity)
O34673 (AlphaFold)
Expression and Regulation
Operons
Genes
yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA
Description
PubMed
Regulation
induced by galacturonate (ExuR) PubMed
Regulatory mechanism
ExuR: repression, in the absence of inducer, in exuR regulon
CcpA: repression, PubMed PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigE: sigma factor, PubMed, in sigE regulon
Open in new tab

yjmC→uxaA

2025-04-03 08:08:36

ghost

92

e9b60dda83535baf9252c89c7130d2fdeb844e6f

417675688A3DB0A933113CA632D3321516D969A2

Genes
uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA
Description
PubMed
Regulation
induced by galacturonate (ExuR) PubMed
Regulatory mechanism
ExuR: repression, in the absence of inducer, in exuR regulon
CcpA: repression, PubMed PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

uxaC→uxaA

2025-04-03 12:22:40

ghost

96

0325999ea185bfaaf2dea87e1701479c52256033

A15F6E93B04DC8C4B59B7976DAC34CE9AC0B8E51

Biological materials
Mutant
MGNA-A374 (yjmJ::erm), available at the NBRP B. subtilis, Japan
BKE12390 (ΔuxaA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTTCAACGTACCTCTCCCCC,  downstream forward: _UP4_TAATAAGAAAAGGCTATCCT
BKK12390 (ΔuxaA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTTCAACGTACCTCTCCCCC,  downstream forward: _UP4_TAATAAGAAAAGGCTATCCT
References
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Time of last update: 2025-04-03 16:03:12

Author of last update: Jstuelk