NrdI

• Description: flavodoxin, ribonucleoside-diphosphate reductase
  
  

Gene name	nrdI
Synonyms	ymaA
Essential	yes PubMed
Product	ribonucleoside-diphosphate reductase
Function	synthesis of deoxyribonucleoside triphosphates
Gene expression levels in SubtiExpress: nrdI
Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation)
MW, pI	14 kDa, 8.58
Gene length, protein length	390 bp, 130 aa
Immediate neighbours	ymzA, nrdE
Gene sequence (+200bp)	Protein sequence
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, essential genes

This gene is a member of the following regulons

ResD regulon

The gene

Basic information

• Locus tag: BSU17370

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: nrdI family (according to Swiss-Prot)

• Paralogous protein(s): YosM

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1RLJ

• UniProt: P50618

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: nrdI-nrdE-nrdF-ymaB PubMed

• Expression browser: nrdI PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under anaerobic conditions (ResD) PubMed

• Regulatory mechanism:
  • ResD: transcription activation PubMed

• Additional information:
  • A ncRNA is predicted between ymzA and nrdI PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

John Herrick, Bianca Sclavi
Ribonucleotide reductase and the regulation of DNA replication: an old story and an ancient heritage.
Mol Microbiol: 2007, 63(1);22-34
[PubMed:17229208] [WorldCat.org] [DOI] (P p)