UxaC

• Description: glucuronate isomerase (D-glucuronate, D-galacturonate)
  
  

Gene name	uxaC
Synonyms	yjmA
Essential	no
Product	glucuronate isomerase (D-glucuronate, D-galacturonate)
Function	hexuronate utilization
MW, pI	54 kDa, 5.174
Gene length, protein length	1419 bp, 473 aa
Immediate neighbours	ndh, yjmB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

CcpA regulon, ExuR regulon

The gene

Basic information

• Locus tag: BSU12300

Expression

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: D-glucuronate = D-fructuronate (according to Swiss-Prot)

• Protein family: uronate isomerase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34808

• KEGG entry: [3]

• E.C. number: 5.3.1.12

Expression and regulation

• Operon: uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (CcpA) PubMed1 PubMed2
  • induced by galacturonate (ExuR) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed1 PubMed2
  • ExuR: reanscription repression in the absence of inducer PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: