DynA

• Description: dynamin-like protein, mediates membrane fusion
  
  

Gene name	dynA
Synonyms	ypbR
Essential	no
Product	dynamin-like protein
Function	fusion of membranes
MW, pI	137 kDa, 5.724
Gene length, protein length	3579 bp, 1193 aa
Immediate neighbours	ypbS, fbpC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

membrane dynamics, membrane proteins

The gene

Basic information

• Locus tag: BSU22030

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: mediates nucleotide independent membrane fusion in vitro PubMed

• Protein family: gerABKA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: two separate dynamin-like subunits and GTPase domains PubMed

• Modification:

• Cofactor(s): Mg(2+) PubMed

• Effectors of protein activity:

• Interactions:
  • forms oligomers PubMed

• Localization: associated to the membrane PubMed

Database entries

• Structure:

• UniProt: P54159

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ypbR PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:
  • A ncRNA is predicted between dynA and bpsB PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Frank Bürmann, Nina Ebert, Suey van Baarle, Marc Bramkamp
A bacterial dynamin-like protein mediating nucleotide-independent membrane fusion.
Mol Microbiol: 2011, 79(5);1294-304
[PubMed:21205012] [WorldCat.org] [DOI] (I p)

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

L Chen, L P James, J D Helmann
Metalloregulation in Bacillus subtilis: isolation and characterization of two genes differentially repressed by metal ions.
J Bacteriol: 1993, 175(17);5428-37
[PubMed:8396117] [WorldCat.org] [DOI] (P p)