dynA

dynA
168

dynamin-like protein, mediates membrane fusion

Locus
BSU_22030
Molecular weight
137.16 kDa
Isoelectric point
5.72
Protein length
1193 aaSequenceBlast
Gene length
3582 bpSequenceBlast
Function
fusion of membranes
Product
dynamin-like protein
Essential
no
Synonyms
dynA, ypbR
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1159 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,312,529  2,316,110
Phenotypes of a mutant
sensitive to membrane stress-inducing antibiotics PubMed
increased sensitivity to phage infection by ɸ29 and SPβ PubMed
The protein
Catalyzed reaction/ biological activity
mediates nucleotide independent membrane fusion in vitro PubMed
causes delay of host cell lysis upon phage infection PubMed
Domains
two separate dynamin-like subunits and GTPase domains PubMed
Cofactors
Mg(2 ) PubMed
Structure
P54159 (AlphaFold)
Localization
associated to the membrane PubMed
membrane, forms foci at the site of septation PubMed
forms large, almost immobile clusters on the cell membrane upon phage infection to support membrane integrity PubMed
colocalizes with FtsZ PubMed
highly dynamic membrane-associated protein; upon membrane damage, DynA localizes into large and static assemblies PubMed
Expression and Regulation
Operons
Genes
dynA-ypbS-ypzF
Description
PubMed
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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dynA-ypbS-ypzF

2025-03-20 21:35:30

Jstuelk

146

177c48e99b386e3cd1a27a0260b3babda43f9eec

615EF1D03BA787E7836A11D5ED69226719C562D0

Biological materials
Mutant
MGNA-A877 (ypbR::erm), available at the NBRP B. subtilis, Japan
BKE22030 (dynA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAAGTCTGAACCCCTTTG,  downstream forward: _UP4_TAAAATTCAGTTGGCTTGTA
BKK22030 (dynA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAAGTCTGAACCCCTTTG,  downstream forward: _UP4_TAAAATTCAGTTGGCTTGTA
References
Reviews
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Original Publications
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Page visits: 5022

Time of last update: 2025-04-02 09:07:07

Author of last update: Jstuelk