ComEA

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• Description: exogenous DNA-binding protein <br/><br/>

Gene name	comEA
Synonyms	comD
Essential	no
Product	exogenous DNA-binding protein
Function	competence
Metabolic function and regulation of this protein in SubtiPathways: <br/>Nucleotides (regulation)
MW, pI	21 kDa, 4.824
Gene length, protein length	615 bp, 205 aa
Immediate neighbours	comEB, comER
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> <div align="right"> <small>This image was kindly provided by SubtiList</small></div>

<br/><br/><br/><br/><br/><br/>

The gene

Basic information

• Locus tag: BSU25590

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2DUY (from Thermus thermophilus hb8, 37% identity, 60% similarity)

• UniProt: P39694

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: comEA-comEB-comEC PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • post-translational control by ComN PubMed
  • yutB is required for transcription PubMed
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>9987128,11814663,7768800,16751195,7968523,17630974,,19028902, </pubmed>