ComN

• Description: mediates post-transcriptional control of comE operon expression
  
  

Gene name	comN
Synonyms	yrzD
Essential	no
Product	post-transcriptional regulator of comE expression
Function	regulation of competence and DNA uptake
Gene expression levels in SubtiExpress: comN
Interactions involving this protein in SubtInteract: ComN
MW, pI	11 kDa, 4.622
Gene length, protein length	294 bp, 98 aa
Immediate neighbours	secDF, spoVB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence, membrane proteins

The gene

Basic information

• Locus tag: BSU27660

Database entries

• BsubCyc: BSU27660

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • post-transcriptional control of comEA expression PubMed
  • promotes the accumulation of its target comEA mRNA to septal and polar sites PubMed
• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • DivIVA-ComN PubMed

• Localization:
  • localizes to the division site and cell poles in a DivIVA dependent fashion PubMed

Database entries

• BsubCyc: BSU27660

• Structure:

• UniProt: O32049

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: comN PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 140 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Valquiria Tiago dos Santos, Alexandre W Bisson-Filho, Frederico J Gueiros-Filho
DivIVA-mediated polar localization of ComN, a posttranscriptional regulator of Bacillus subtilis.
J Bacteriol: 2012, 194(14);3661-9
[PubMed:22582279] [WorldCat.org] [DOI] (I p)

Mitsuo Ogura, Teruo Tanaka
The Bacillus subtilis late competence operon comE is transcriptionally regulated by yutB and under post-transcription initiation control by comN (yrzD).
J Bacteriol: 2009, 191(3);949-58
[PubMed:19028902] [WorldCat.org] [DOI] (I p)