AcdA

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• Description: acyl-CoA dehydrogenase <br/><br/>

Gene name	acdA
Synonyms
Essential	no
Product	acyl-CoA dehydrogenase
Function	fatty acid degradation
Metabolic function and regulation of this protein in SubtiPathways: <br/>Fatty acid degradation
MW, pI	41 kDa, 4.951
Gene length, protein length	1137 bp, 379 aa
Immediate neighbours	rpoE, fadF
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> <div align="right"> <small>This image was kindly provided by SubtiList</small></div>

<br/><br/><br/><br/><br/><br/>

The gene

Basic information

• Locus tag: BSU37170

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF (according to Swiss-Prot)

• Protein family: acyl-CoA dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s): YngJ, MmgC, FadE

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2Z1Q (from Thermus thermophilus hb8, 40% identity, 55% similarity)

• UniProt: P45867

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: fadF-acdA-rpoE PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed in the absence of long-chain fatty acids (FadR) PubMed

• Regulatory mechanism:
  • FadR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

<pubmed>17189250,17919287</pubmed>