DegU

• Description: two-component response regulator that controls degradative enzyme synthesis and genetic competence
  
  

Gene name	degU
Synonyms	sacU, iep
Essential	no
Product	two-component response regulator
Function	control of degradative enzyme synthesis and of genetic competence
MW, pI	25 kDa, 5.602
Gene length, protein length	687 bp, 229 aa
Immediate neighbours
Gene sequence (+200bp)	Protein sequence
Genetic context

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcription activator of degradative enzyme genes (sacB and degQ) and of comK expression

• Protein family:

• Paralogous protein(s):

Genes controlled by DegU

• Activation by DegU: degS-degU

• Repression by DegU:

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation by DegS modulates DNA-binding activity

• Cofactor(s):

• Effectors of protein activity:

• Interactions: DegS-DegU

• Localization:

Database entries

• Structure:

• Swiss prot entry:

• KEGG entry:

• E.C. number:

Expression and regulation

• Operon: degS-degU

• Sigma factor: SigA

• Regulation: induced in the presence of ammonium (TnrA)

• Regulatory mechanism: TnrA: repression, DegU: positive autoregulation

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed