AcuA

• Description: protein acetylase for the control of AcsA activity
  
  

Gene name	acuA
Synonyms
Essential	no
Product	Gcn5-related N-acetyltransferase
Function	control of AcsA activity
MW, pI	24 kDa, 5.028
Gene length, protein length	630 bp, 210 aa
Immediate neighbours	acsA, acuB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources, utilization of lipids, protein modification

This gene is a member of the following regulons

CcpA regulon

The gene

Basic information

• Locus tag: BSU29690

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: acetylates (and thereby inactivates) AcsA on Lys-549 PubMed PubMed

• Protein family: acetyltransferase family (according to Swiss-Prot) Gcn5-relatedN-acetyltransferase PubMed

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P39065

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: acuA-acuB-acuC PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (3.4-fold) (CcpA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • GP1211 (acuA::kan), available in Jörg Stülke's lab
  • GP1255 (acuA::kan yjcK::cat ynaD::spec yoaA::tet), available in Jörg Stülke's lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: