FlgM

• Description: anti-SigD, regulation of flagellin, motility, and chemotaxis
  
  

Gene name	flgM
Synonyms
Essential	no
Product	anti-SigD
Function	control of SigD activity
Gene expression levels in SubtiExpress: flgM
Interactions involving this protein in SubtInteract: FlgM
MW, pI	9 kDa, 9.918
Gene length, protein length	264 bp, 88 aa
Immediate neighbours	flgN, yvyF
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sigma factors and their control, motility and chemotaxis

This gene is a member of the following regulons

ComK regulon, DegU regulon, ScoC regulon, SigD regulon

The gene

Basic information

• Locus tag: BSU35430

Database entries

• BsubCyc: BSU35430

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: flgM family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions: FlgM-SigD PubMed

• Localization:

Database entries

• BsubCyc: BSU35430

• Structure:

• UniProt: P39809

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • comFA-comFB-comFC-yvyF-flgM-flgN-flgK-flgL PubMed
  • yvyF-flgM-flgN-flgK-flgL PubMed
  • flgM-flgN-flgK-flgL PubMed

• Expression browser: flgM PubMed

• Sigma factor:
  • comFA: SigA PubMed
  • yvyF: SigD PubMed
  • flgM: SigD PubMed

• Regulation:

• Regulatory mechanism:
  • ComK: transcription activation PubMed
  • ScoC: transcription repression PubMed
  • flgM: DegU-P: transcription activation PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A764 (no resistance), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Sampriti Mukherjee, Daniel B Kearns
The structure and regulation of flagella in Bacillus subtilis.
Annu Rev Genet: 2014, 48;319-40
[PubMed:25251856] [WorldCat.org] [DOI] (I p)