Difference between revisions of "GyrA"
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|colspan="2" | '''Genetic context''' <br/> [[Image:GyrA_context.png]] | |colspan="2" | '''Genetic context''' <br/> [[Image:GyrA_context.png]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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| + | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=gyrA_6994_9459_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:gyrA_expression.png|500px]] | ||
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Revision as of 12:11, 18 April 2012
- Description: DNA gyrase (subunit A)
| Gene name | gyrA |
| Synonyms | nalA |
| Essential | yes PubMed |
| Product | DNA gyrase (subunit A) |
| Function | DNA supercoiling, initation of replication cycle and DNA elongation |
| Interactions involving this protein in SubtInteract: GyrA | |
| MW, pI | 91 kDa, 5.215 |
| Gene length, protein length | 2463 bp, 821 aa |
| Immediate neighbours | gyrB, rrnO-16S |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
DNA condensation/ segregation, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU00070
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to Swiss-Prot)
- Protein family: topoisomerase gyrA/parC subunit family (according to Swiss-Prot)
- Paralogous protein(s): ParC
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P05653
- KEGG entry: [3]
- E.C. number:
Additional information
- subject to Clp-dependent proteolysis upon glucose starvation PubMed
Expression and regulation
- Operon: gyrA PubMed
- Regulation:
- Regulatory mechanism:
- Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed, GyrA is subject to Clp-dependent proteolysis upon glucose starvation PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Dagmar Klostermeier, Biozentrum Basel, Switzerland homepage
Your additional remarks
References
Additional references: PubMed
