gyrA
168
DNA gyrase (subunit A)
Locus
BSU_00070
Molecular weight
91.91 kDa
Isoelectric point
5.22
Function
DNA supercoiling, control of replication initiation, resolution of head-on DNA replication-Transcription conflicts
Product
DNA gyrase (subunit A)
Essential
yes
E.C.
5.99.1.3
Synonyms
gyrA, nalA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0188 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
6,994 → 9,459
Phenotypes of a mutant
The protein
Catalyzed reaction/ biological activity
ATP-dependent breakage, passage and rejoining of double-stranded DNA (according to UniProt)
Protein family
Structure
9GBV (PDB) (E. coli DNA gyrase with chirally wrapped 217 bp DNA fragment) PubMed
9GGQ (PDB) (E. coli DNA gyrase with chirally wrapped 217 bp DNA fragment in the presence of the fluoroquinolone moxifloxacin) PubMed
4DDQ (PDB) (DNA gyrase A-subunit lacking the C-terminal DNA-wrapping domains) PubMed
Paralogous protein(s)
Expression and Regulation
Operons
Labs working on this gene/protein
Dagmar Klostermeier, University of Münster, Germany, homepage
References
Reviews
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Original Publications
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Time of last update: 2025-03-31 20:44:24
Author of last update: Jstuelk