ExuR

• Description: repression of the hexuronate utilization operon (uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA)
  
  

Gene name	exuR
Synonyms	yjmH
Essential	no
Product	transcriptional repressor (LacI family)
Function	regulation of hexuronate utilization
MW, pI	37 kDa, 5.846
Gene length, protein length	999 bp, 333 aa
Immediate neighbours	exuT, uxaB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, sporulation proteins

This gene is a member of the following regulons

CcpA regulon, ExuR regulon, SigE regulon

The ExuR regulon:

• uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA

The gene

Basic information

• Locus tag: BSU12370

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: LacI family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: galacturonate acts as the molecular inducer PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: Q9JMQ1

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed
  • yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed

• Sigma factor: SigE PubMed
  • uxaC: SigA PubMed
  • yjmC: SigE PubMed

• Regulation:
  • repressed by glucose (CcpA) PubMed1 PubMed2
  • induced by galacturonate (ExuR) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed1 PubMed2
  • ExuR: reanscription repression in the absence of inducer PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: