Difference between revisions of "HisA"
| Line 58: | Line 58: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU34880&redirect=T BSU34880] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
| Line 96: | Line 97: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU34880&redirect=T BSU34880] | ||
* '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2VEP 2VEP] (from ''Streptomyces coelicolor'', 41% identity, 58% similarity) {{PubMed|17967415}} | * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2VEP 2VEP] (from ''Streptomyces coelicolor'', 41% identity, 58% similarity) {{PubMed|17967415}} | ||
Revision as of 14:53, 2 April 2014
- Description: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, homologue to HisF
| Gene name | hisA |
| Synonyms | |
| Essential | no |
| Product | phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, homologue to HisF |
| Function | biosynthesis of histidine |
| Gene expression levels in SubtiExpress: hisA | |
| Metabolic function and regulation of this protein in SubtiPathways: hisA | |
| MW, pI | 26 kDa, 4.842 |
| Gene length, protein length | 735 bp, 245 aa |
| Immediate neighbours | hisF, hisH |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU34880
Phenotypes of a mutant
Database entries
- BsubCyc: BSU34880
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide (according to Swiss-Prot)
- Protein family: hisA/hisF family (according to Swiss-Prot)
- Paralogous protein(s): HisF
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cytoplasm (according to Swiss-Prot)
Database entries
- BsubCyc: BSU34880
- UniProt: O35006
- KEGG entry: [2]
- E.C. number: 5.3.1.16
Additional information
Expression and regulation
- Sigma factor:
- Regulation: repressed by casamino acids PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
