hisD

hisD
168

histidinol dehydrogenase

Locus
BSU_34910
Molecular weight
46.09 kDa
Isoelectric point
4.78
Protein length
427 aaSequenceBlast
Gene length
1284 bpSequenceBlast
Function
biosynthesis of histidine
Product
histidinol dehydrogenase
Essential
no
E.C.
1.1.1.23
Synonyms
hisD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0141 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,586,271  3,587,554
The protein
Catalyzed reaction/ biological activity
H2O + L-histidinol + 2 NAD+ --> 3 H+ + L-histidine + 2 NADH (according to UniProt)
Protein family
histidinol dehydrogenase family (single member, according to UniProt)
Structure
1KAH (PDB) (with product and NAD from Escherichia coli, 39% identity, 58% similarity) PubMed
O34651 (AlphaFold)
Expression and Regulation
Operons
Genes
hisZ-hisG-hisD-hisB-hisH-hisA-hisF-hisI
Description
PubMed
Regulation
expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
expression depends on functional RnpM PubMed
Regulatory mechanism
RnpM: unknown, PubMed, in rnpM regulon
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hisZ→hisI

2025-04-03 14:03:13

Jstuelk

133

896e17f5309df81d9427f38fec175515ad428723

B6AAF7601668444EDDC2FE084A87885740B98ACD

Biological materials
Mutant
BKE34910 (hisD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CGCTCCGCTGATGGTTTTGA,  downstream forward: _UP4_GCGAGAGAACGGAGGATTTC
BKK34910 (hisD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CGCTCCGCTGATGGTTTTGA,  downstream forward: _UP4_GCGAGAGAACGGAGGATTTC
References
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03274B80B2DFE0A2939981B0E0CB8C34A9B0B102

Page visits: 2560

Time of last update: 2025-04-03 14:58:55

Author of last update: Melvin.boenninger