TcyM

• Description: cystine ABC transporter (permease)
  
  

Gene name	tcyM
Synonyms	ytmM
Essential	no
Product	cystine ABC transporter (permease)
Function	cystine uptake
Gene expression levels in SubtiExpress: tcyM
Interactions involving this protein in SubtInteract: TcyM
Metabolic function and regulation of this protein in SubtiPathways: Riboflavin / FAD
MW, pI	25 kDa, 8.767
Gene length, protein length	705 bp, 235 aa
Immediate neighbours	tcyN, tcyL
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, biosynthesis/ acquisition of amino acids, membrane proteins

This gene is a member of the following regulons

CymR regulon, AscR regulon

The gene

Basic information

• Locus tag: BSU29350

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: binding-protein-dependent transport system permease family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • TcyN-(TcyL-TcyM)-(TcyJ-TcyK) PubMed

• Localization:
  • cell membrane PubMed

Database entries

• Structure:

• UniProt: O34931

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: snaA-tcyJ-tcyK-tcyL-tcyM-tcyN-cmoO-cmoI-cmoJ-ribR-sndA-ytnM PubMed

• Expression browser: tcyM PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed in the presence of cysteine (CymR) PubMed
  • induced in the presence of S-methyl-cysteine (AscR) PubMed

• Regulatory mechanism:
  • CymR: transcription repression PubMed
  • AscR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A948 ( tcyM::kan), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: