Spx regulon

Regulator	Spx
Overview on the regulons (wiki page) Overview on the regulons (Excel file)

Genes in this regulon

Activation

• cysK
• mccA-mccB
• msrA
• msrB
• mtnN
• nfrA
• tpx
• trxA
• trxB
• ylaA
• ylaB
• ylaC
• ylaD
• ylbQ-bshC
• yoyC-yojF-bshB2
• ypjD-dapB-mgsA-bshB1-bshA-cca-birA
• yrhC
• yrrT
• ytpP-ytpQ-ytpR
• ytvA
• yugJ
• yugT

Repression

• srfAA-srfAB-comS-srfAC-srfAD

Important publications on the Spx regulon

Daniel F Rojas-Tapias, John D Helmann
Induction of the Spx regulon by cell wall stress reveals novel regulatory mechanisms in Bacillus subtilis.
Mol Microbiol: 2018, 107(5);659-674
[PubMed:29271514] [WorldCat.org] [DOI] (I p)

Tatiana Rochat, Pierre Nicolas, Olivier Delumeau, Alžbeta Rabatinová, Jana Korelusová, Aurélie Leduc, Philippe Bessières, Etienne Dervyn, Libor Krásny, Philippe Noirot
Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis.
Nucleic Acids Res: 2012, 40(19);9571-83
[PubMed:22904090] [WorldCat.org] [DOI] (I p)

Kyle N Erwin, Shunji Nakano, Peter Zuber
Sulfate-dependent repression of genes that function in organosulfur metabolism in Bacillus subtilis requires Spx.
J Bacteriol: 2005, 187(12);4042-9
[PubMed:15937167] [WorldCat.org] [DOI] (P p)

Peter Zuber
Spx-RNA polymerase interaction and global transcriptional control during oxidative stress.
J Bacteriol: 2004, 186(7);1911-8
[PubMed:15028674] [WorldCat.org] [DOI] (P p)

Shunji Nakano, Elke Küster-Schöck, Alan D Grossman, Peter Zuber
Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2003, 100(23);13603-8
[PubMed:14597697] [WorldCat.org] [DOI] (P p)