ResE

• Description: two-component sensor kinase, regulation of aerobic and anaerobic respiration
  
  

Gene name	resE
Synonyms	ypxE
Essential	no
Product	two-component sensor kinase
Function	regulation of aerobic and anaerobic respiration
Interactions involving this protein in SubtInteract: ResE
MW, pI	66 kDa, 5.344
Gene length, protein length	1767 bp, 589 aa
Immediate neighbours	sigX, resD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

regulators of electron transport, protein modification, transcription factors and their control, membrane proteins, phosphoproteins

This gene is a member of the following regulons

CcpA regulon, PhoP regulon, ResD regulon

The gene

Basic information

• Locus tag: BSU23110

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of ResD

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain

• Modification: autophosphorylation on a His residue

• Cofactor(s):

• Effectors of protein activity:

• Interactions: ResE-ResD

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P35164

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • resA-resB-resC-resD-resE PubMed
  • resD-resE PubMed

• Sigma factor:
  • resA: SigA PubMed
  • resD: SigA PubMed

• Regulation:
  • expressed under anaerobic conditions (ResD) PubMed
  • expressed under conditions of phosphate limitation (PhoP) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • ResD: transcription activation PubMed
  • PhoP: transcription activation PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: