TreP

• Description: trehalose-specific phosphotransferase system, EIIBC component of the PTS
  
  

Gene name	treP
Synonyms	treB
Essential	no
Product	trehalose-specific phosphotransferase system, EIIBC component
Function	trehalose uptake and phosphorylation
Interactions involving this protein in SubtInteract: TreP
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	49 kDa, 8.555
Gene length, protein length	1410 bp, 470 aa
Immediate neighbours	yfkQ, treA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, membrane proteins, phosphoproteins

This gene is a member of the following regulons

CcpA regulon, PhoP regulon, TreR regulon

The gene

Basic information

• Locus tag: BSU07800

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate (according to Swiss-Prot)

• Protein family: PTS permease, sucrose permease (Scr) family PubMed

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P39794

• KEGG entry: [2]

• E.C. number: 2.7.1.69

Expression and regulation

• Operon: treP-treA-treR PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by trehalose (TreR) PubMed
  • repressed by glucose (CcpA) PubMed
  • expressed under conditions of phosphate limitation (PhoP) PubMed

• Regulatory mechanism:
  • TreR: transcription repression PubMed
  • CcpA: transcription repression PubMed
  • PhoP: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed