treA

treA
168

phospho-alpha-glucosidase

Locus
BSU_07810
Molecular weight
65.01 kDa
Isoelectric point
4.89
Protein length
561 aaSequenceBlast
Gene length
1686 bpSequenceBlast
Function
trehalose utilization
Product
phospho-alpha-glucosidase
Essential
no
E.C.
3.2.1.93
Synonyms
treA, treC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0366 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
851,850  853,535
The protein
Catalyzed reaction/ biological activity
α,α-trehalose 6-phosphate + H2O --> D-glucose + D-glucose 6-phosphate (according to UniProt)
Protein family
glycosyl hydrolase 13 family (according to UniProt)
Structure
5BRQ (PDB) (from B. licheniformis, 73% identity) PubMed
P39795 (AlphaFold)
Paralogous protein(s)
MalL, YcdG, YugT
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
treP-treA-treR
Description
PubMed
Regulation
expressed under conditions of phosphate limitation (PhoP) PubMed
Regulatory mechanism
TreR: repression, PubMed, in treR regulon
CcpA: repression, PubMed, in ccpA regulon
PhoP: activation, PubMed, in phoP regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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treP→treR

2025-03-17 20:06:09

ghost

96

5ea0c439875fc22b9a05971658c7c0a460d25052

9C91E3C2B12C6666EE92EE6C971F82C82DDCB383

Biological materials
Mutant
MGNA-C260 (treA::erm), available at the NBRP B. subtilis, Japan
GP1118 (spc), available in Jörg Stülke's lab
BKE07810 (treA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTGTTTCCACCACCATA,  downstream forward: _UP4_TAAACTAAGCTGGGTGGTCC
BKK07810 (treA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTGTTTCCACCACCATA,  downstream forward: _UP4_TAAACTAAGCTGGGTGGTCC
References
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2EB9E0C492DF57DF683817E31D6DD34D7580E631

Page visits: 5944

Time of last update: 2025-04-02 18:24:28

Author of last update: Melvin.boenninger