ComEC

• Description: channel protein for DNA binding and uptake
  
  

Gene name	comEC
Synonyms	comD
Essential	no
Product	DNA channel
Function	genetic competence
Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation), Protein secretion
MW, pI	86 kDa, 6.964
Gene length, protein length	2328 bp, 776 aa
Immediate neighbours	holA, comEB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

ComK regulon, ComN regulon

The gene

Basic information

• Locus tag: BSU25570

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • ComEC-ComEA PubMed
  • ComEC-ComFA PubMed
  • ComEC-ComGA PubMed

• Localization:
  • cell membrane PubMed
  • localizes to one or both cell poles PubMed

Database entries

• Structure:

• UniProt: P39695

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: comEA-comEB-comEC PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • post-translational control by ComN PubMed
  • yutB is required for transcription PubMed
  • ComK: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159] [WorldCat.org] [DOI] (P p)