AcdA

• Description: acyl-CoA dehydrogenase
  
  

Gene name	acdA
Synonyms
Essential	no
Product	acyl-CoA dehydrogenase
Function	fatty acid degradation
Metabolic function and regulation of this protein in SubtiPathways: Fatty acid degradation
MW, pI	41 kDa, 4.951
Gene length, protein length	1137 bp, 379 aa
Immediate neighbours	rpoE, fadF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU37170

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF (according to Swiss-Prot)

• Protein family: acyl-CoA dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s): YngJ, MmgC, FadE

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2Z1Q (from Thermus thermophilus hb8, 40% identity, 55% similarity)

• UniProt: P45867

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: fadF-acdA-rpoE PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed in the absence of long-chain fatty acids (FadR) PubMed

• Regulatory mechanism:
  • FadR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: