Difference between revisions of "SecA"
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=Expression and regulation= | =Expression and regulation= | ||
| + | * '''Operon:''' ''[[secA]]-[[prfB]]'' {{PubMed|9882663}} | ||
| − | * | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|9882663}} |
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| − | |||
* '''Regulation:''' | * '''Regulation:''' | ||
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* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | * '''Additional information:''' subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=+17981983 PubMed] | + | * '''Additional information:''' |
| + | ** subject to Clp-dependent proteolysis upon glucose starvation [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=+17981983 PubMed] | ||
=Biological materials = | =Biological materials = | ||
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=References= | =References= | ||
| − | <pubmed>19933328, 19924216, 18923516,12873133,12242434,1385592,10816431,19850053 ,9880811, </pubmed> | + | <pubmed>19933328, 19924216, 18923516,12873133,12242434,1385592,10816431,19850053 ,9880811, 12218047 17981983 9882663</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 22:19, 30 December 2009
- Description: preprotein translocase subunit (ATPase)
| Gene name | secA |
| Synonyms | div, div-341, ts-341 |
| Essential | yes PubMed |
| Product | preprotein translocase subunit (ATPase) |
| Function | protein secretion |
| MW, pI | 95 kDa, 5.34 |
| Gene length, protein length | 2523 bp, 841 aa |
| Immediate neighbours | prfB, yvyD |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU35300
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP -> ADP + Pi + preprotein translocation
- Protein family: SecA family (according to Swiss-Prot)
- Paralogous protein(s): none in Bacillus, some species have a paralogous secA gene named secA2 that has an altered substrate range
Extended information on the protein
- Kinetic information:
- Domains: nucleotide binding domain, preprotein binding domain, IRA2 domain, scaffold domain, wing domain, IRA1 domain, C-terminal domain
- Modification:
- Cofactor(s): magnesium
- Effectors of protein activity: anionic phospholipids, preprotein, SecY, signal peptides (even when added in trans) PubMed
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- UniProt: P28366
- KEGG entry: [3]
- E.C. number:
Additional information
- subject to Clp-dependent proteolysis upon glucose starvation PubMed
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
- subject to Clp-dependent proteolysis upon glucose starvation PubMed
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
