Difference between revisions of "HisD"
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=Expression and regulation= | =Expression and regulation= | ||
| − | + | * '''Operon:''' ''[[hisZ]]-[[hisG]]-[[hisD]]-[[hisB]]-[[hisH]]-[[hisA]]-[[hisF]]-[[hisI]]'' {{PubMed|12107147}} | |
| − | * '''Operon:''' | ||
* '''[[Sigma factor]]:''' | * '''[[Sigma factor]]:''' | ||
| − | * '''Regulation:''' repressed by casamino acids | + | * '''Regulation:''' repressed by casamino acids {{PubMed|12107147}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 11:57, 30 December 2009
- Description: histidinol dehydrogenase
| Gene name | hisD |
| Synonyms | |
| Essential | no |
| Product | histidinol dehydrogenase |
| Function | biosynthesis of histidine |
| Metabolic function and regulation of this protein in SubtiPathways: His | |
| MW, pI | 46 kDa, 4.777 |
| Gene length, protein length | 1281 bp, 427 aa |
| Immediate neighbours | hisB, hisG |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU34910
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: L-histidinol + 2 NAD+ = L-histidine + 2 NADH (according to Swiss-Prot)
- Protein family: histidinol dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O34651
- KEGG entry: [2]
- E.C. number: 1.1.1.23
Additional information
Expression and regulation
- Regulation: repressed by casamino acids PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147]
[WorldCat.org]
[DOI]
(P p)
