Difference between revisions of "Fur"
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
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− | |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional repressor | + | |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional repressor [[Fur family]] |
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of iron homoeostasis | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of iron homoeostasis | ||
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* '''Catalyzed reaction/ biological activity:''' | * '''Catalyzed reaction/ biological activity:''' | ||
− | * '''Protein family:''' Fur family | + | * '''Protein family:''' [[Fur family]] |
* '''Paralogous protein(s):''' [[PerR]], [[Zur]] | * '''Paralogous protein(s):''' [[PerR]], [[Zur]] |
Revision as of 16:37, 17 July 2012
- Description: transcription regulator of iron homoeostasis
Gene name | fur |
Synonyms | yqkL |
Essential | no |
Product | transcriptional repressor Fur family |
Function | regulation of iron homoeostasis
and transcription of ferri-siderophore uptake genes |
Metabolic function and regulation of this protein in SubtiPathways: Metal ion homeostasis, Alternative nitrogen sources, Protein secretion | |
MW, pI | 17 kDa, 5.374 |
Gene length, protein length | 447 bp, 149 aa |
Immediate neighbours | ripX, spoIIM |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
iron metabolism, transcription factors and their control
- see also: glutamate metabolism
This gene is a member of the following regulons
The Fur regulon
The gene
Basic information
- Locus tag: BSU23520
Phenotypes of a mutant
- no growth with glucose and ammonium as single sources of carbon and nitrogen, respectively (due to FsrA-mediated repression of the gltA-gltB operon) PubMed
- poor frowth on lactate as single carbon source (due to overexpression of FsrA-mediated repression of the lutA-lutB-lutC operon, can be suppressed by inactivation of fsrA or fbpB) PubMed
- transcription profile of a fur mutant strain: GEO PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: Fur family
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): contains an iron-sulfur cluster
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P54574
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: fur PubMed
- Additional information:
Biological materials
- Mutant: HB6543 (aphA3), available in the John Helmann lab; also available in the Stülke lab GP879 (fur::mls) and GP868 (fur::mls, perR::spc)
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Reviews
Charles M Moore, John D Helmann
Metal ion homeostasis in Bacillus subtilis.
Curr Opin Microbiol: 2005, 8(2);188-95
[PubMed:15802251]
[WorldCat.org]
[DOI]
(P p)
The Fur regulon
Addititonal publications: PubMed
Gregory T Smaldone, Olga Revelles, Ahmed Gaballa, Uwe Sauer, Haike Antelmann, John D Helmann
A global investigation of the Bacillus subtilis iron-sparing response identifies major changes in metabolism.
J Bacteriol: 2012, 194(10);2594-605
[PubMed:22389480]
[WorldCat.org]
[DOI]
(I p)
Noel Baichoo, John D Helmann
Recognition of DNA by Fur: a reinterpretation of the Fur box consensus sequence.
J Bacteriol: 2002, 184(21);5826-32
[PubMed:12374814]
[WorldCat.org]
[DOI]
(P p)
Noel Baichoo, Tao Wang, Rick Ye, John D Helmann
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon.
Mol Microbiol: 2002, 45(6);1613-29
[PubMed:12354229]
[WorldCat.org]
[DOI]
(P p)
Other original publications