FsrA

• Description: regulatory RNA
  
  

Gene name	fsrA
Synonyms
Essential	no
Product	sRNA FsrA
Function	inhibition of sdhC translation
Gene length	aaa bp
Immediate neighbours	ykuI, ykuJ
Gene sequence (+200bp)
Genetic context

Categories containing this gene/protein

carbon core metabolism, acquisition of iron, ncRNA

This gene is a member of the following regulons

Fur regulon

The FsrA regulon

The gene

Basic information

• Locus tag:

Phenotypes of a mutant

• transcription profile of a fsrA mutant strain: GEO PubMed

Database entries

• BsubCyc: ?
• BsubCyc: ?

• DBTBS entry: no entry

• SubtiList entry: no entry

• GEO entry: GEO PubMed

• Structure:

Additional information

• Swiss prot entry:

• KEGG entry: no entry

• E.C. number:

Additional information

The RNA

Basic information/ Evolution

• Catalyzed reaction/ biological activity: hybridizes to sdhC, citB, lutB, gltA-gltB, and leuC-leuD mRNAs and inhibits their translation. PubMed

Extended information on the RNA

• Kinetic information

• Interactions:
  • Binds sdhC, citB, lutB, gltA-gltB, and leuC-leuD mRNAs PubMed

• Localization

Database entries

• BsubCyc: ?
• BsubCyc: ?

• Structure:

Additional information

Expression and regulation

• Operon:

• Sigma factor:

• Regulation: induced by iron starvation (Fur) PubMed

• Regulatory mechanism: Fur: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

Labs working on this gene/RNA

John Helmann, Cornell University, USA Homepage

Your additional remarks

References

Gregory T Smaldone, Haike Antelmann, Ahmed Gaballa, John D Helmann
The FsrA sRNA and FbpB protein mediate the iron-dependent induction of the Bacillus subtilis lutABC iron-sulfur-containing oxidases.
J Bacteriol: 2012, 194(10);2586-93
[PubMed:22427629] [WorldCat.org] [DOI] (I p)

Gregory T Smaldone, Olga Revelles, Ahmed Gaballa, Uwe Sauer, Haike Antelmann, John D Helmann
A global investigation of the Bacillus subtilis iron-sparing response identifies major changes in metabolism.
J Bacteriol: 2012, 194(10);2594-605
[PubMed:22389480] [WorldCat.org] [DOI] (I p)

Ahmed Gaballa, Haike Antelmann, Claudio Aguilar, Sukhjit K Khakh, Kyung-Bok Song, Gregory T Smaldone, John D Helmann
The Bacillus subtilis iron-sparing response is mediated by a Fur-regulated small RNA and three small, basic proteins.
Proc Natl Acad Sci U S A: 2008, 105(33);11927-32
[PubMed:18697947] [WorldCat.org] [DOI] (I p)