Difference between revisions of "MutTA"
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| − | * '''Description:''' error prevention oxidized guanine system, confers protection against oxidative stress to vegetative cells <br/><br/> | + | * '''Description:''' error prevention oxidized guanine system, confers protection against oxidative stress to vegetative cells, moreover the protein has RNA pyrophosphohydrolase activity <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|''mutTA'' | |''mutTA'' | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ytkD'' | + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ytkD'', ''rppH'' |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || 8-oxo-dGTPase (antimutator) | + | |style="background:#ABCDEF;" align="center"| '''Product''' || 8-oxo-dGTPase (antimutator), RNA pyrophosphohydrolase |
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair | + | |style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair, RNA degradation |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 18 kDa, 5.952 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 18 kDa, 5.952 | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' |
| + | ** removal of pyrophosphate from the 5' end of mRNAs to make the RNA accessible for degradation by [[RNases]] {{PubMed|21925382}} | ||
* '''Protein family:''' [[Nudix hydrolase]] family (according to Swiss-Prot) | * '''Protein family:''' [[Nudix hydrolase]] family (according to Swiss-Prot) | ||
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=References= | =References= | ||
| − | <pubmed>16513759,16497325, 14761999, 19011023 9387221 15576788 </pubmed> | + | <pubmed>16513759,16497325, 14761999, 19011023 9387221 15576788 21925382 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:55, 20 September 2011
- Description: error prevention oxidized guanine system, confers protection against oxidative stress to vegetative cells, moreover the protein has RNA pyrophosphohydrolase activity
| Gene name | mutTA |
| Synonyms | ytkD, rppH |
| Essential | no |
| Product | 8-oxo-dGTPase (antimutator), RNA pyrophosphohydrolase |
| Function | DNA repair, RNA degradation |
| MW, pI | 18 kDa, 5.952 |
| Gene length, protein length | 474 bp, 158 aa |
| Immediate neighbours | ytlD, ytkC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
DNA repair/ recombination, sporulation proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU30630
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: Nudix hydrolase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O35013
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
