Difference between revisions of "Spo0A"
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{{SubtiWiki regulon|[[SigH regulon]]}}, | {{SubtiWiki regulon|[[SigH regulon]]}}, | ||
{{SubtiWiki regulon|[[Spo0A regulon]]}} | {{SubtiWiki regulon|[[Spo0A regulon]]}} | ||
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| + | =The [[Spo0A regulon]]= | ||
=The gene= | =The gene= | ||
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
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=== Extended information on the protein === | === Extended information on the protein === | ||
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==Reviews== | ==Reviews== | ||
<pubmed>19995980 20030732 20157337 11286862 20833318 20955377 </pubmed> | <pubmed>19995980 20030732 20157337 11286862 20833318 20955377 </pubmed> | ||
| − | == | + | ==The [[Spo0A regulon]]== |
| − | <pubmed>20413551 20404177 19528067, 19581368 , 8730857,2106683,3157992, 11254139 | + | <pubmed>14651647,15687200, </pubmed> |
| + | ==Other original Publications== | ||
| + | <pubmed>14679239, 1569009 20413551 20404177 19528067, 19581368 , 8730857,2106683,3157992, 11254139, 12067336, 10869437, 16385044,9287005, 8127878,9287022, 8231806, 1905258,16452424,2118505,8207022, 12176382, 9733708, 11069677,1391039,12730135, 2437099,8288522,16166384,9495766,2118512,1556084, 18296515,7768874, 3145384, 19114652 20689749 1537790,9658000, 8509330,14762002, 1846779, 2981817, 9477965,8600030, 18840696, 1391039, 14976210, 19207565 11679073 12270811 11112444 18978066 20154131 14712656 17157871 15060025 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 21:01, 20 December 2010
- Description: phosphorelay regulator, initiation of sporulation
| Gene name | spo0A |
| Synonyms | spo0C, spo0G, spoIIL, sof-1 |
| Essential | no |
| Product | phosphorelay response regulator |
| Function | initiation of sporulation |
| Metabolic function and regulation of this protein in SubtiPathways: Biofilm, Nucleotides (regulation), Ammonium/ glutamate, Central C-metabolism,Sugar catabolism, Phosphorelay, Stress, tRNA charging,Lipid synthesis, Protein secretion | |
| MW, pI | 29 kDa, 5.989 |
| Gene length, protein length | 801 bp, 267 aa |
| Immediate neighbours | yqiG, spoIVB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
transcription factors and their control, phosphorelay, phosphoproteins
This gene is a member of the following regulons
The Spo0A regulon
The gene
Basic information
- Locus tag: BSU24220
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: receives phosphorylation from Spo0B, dephosphorylation by Spo0E, direct phosphorylation by KinC upon potassium leakage PubMed
- Cofactor(s):
- Effectors of protein activity: the phosphorylation state affects DNA binding activity
- Localization:
Database entries
- Structure: 1QMP (with phosphorylated aspartate, Geobacillus stearothermophilus), 1FC3 (trans-activation domain, Geobacillus stearothermophilus), 1LQ1 (complex with DNA)
- UniProt: P06534
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: spo0A PubMed
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
- Tony Wilkinson, York University, U.K. homepage
- Imrich Barak, Slovak Academy of Science, Bratislava, Slovakia homepage
- Charles Moran, Emory University, NC, USA homepage
Your additional remarks
References
Reviews
The Spo0A regulon
Masaya Fujita, José Eduardo González-Pastor, Richard Losick
High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis.
J Bacteriol: 2005, 187(4);1357-68
[PubMed:15687200]
[WorldCat.org]
[DOI]
(P p)
Virginie Molle, Masaya Fujita, Shane T Jensen, Patrick Eichenberger, José E González-Pastor, Jun S Liu, Richard Losick
The Spo0A regulon of Bacillus subtilis.
Mol Microbiol: 2003, 50(5);1683-701
[PubMed:14651647]
[WorldCat.org]
[DOI]
(P p)
Other original Publications
