Difference between revisions of "DegU"

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{{SubtiWiki regulon|[[DegU regulon]]}},
 
{{SubtiWiki regulon|[[DegU regulon]]}},
 
{{SubtiWiki regulon|[[TnrA regulon]]}}
 
{{SubtiWiki regulon|[[TnrA regulon]]}}
 
+
=The [[DegU regulon]]=
 
=The gene=
 
=The gene=
  
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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Paralogous protein(s):'''
 
* '''Paralogous protein(s):'''
 
=== Genes controlled by DegU ===
 
 
* '''Activation by DegU-P:''' ''[[degS]]-[[degU]]'', ''[[capB]]-[[capC]]-[[capA]]-[[ywtC]]'' {{PubMed|19734658}}
 
 
* '''Activation by DegU:''' ''[[epr]]'' [http://www3.interscience.wiley.com/journal/122328658/abstract PubMed]
 
 
* Repression by DegU-P: ''[[tkmA]]-[[ptkA]]-[[ptpZ]]-[[ugd]]'' {{PubMed|20815827}}
 
  
 
=== Extended information on the protein ===
 
=== Extended information on the protein ===

Revision as of 10:55, 12 December 2010

  • Description: two-component response regulator, regulation of degradative enzyme and genetic competence, involved in activation of capsule biosynthetic operon expression (together with SwrAA), non-phosphorylated DegU is required for swarming motility PubMed

Gene name degU
Synonyms sacU, iep
Essential no
Product two-component response regulator
Function regulation of degradative enzyme and genetic competence
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 25 kDa, 5.602
Gene length, protein length 687 bp, 229 aa
Immediate neighbours yviA, degS
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
DegU context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

DegU regulon, TnrA regulon

The DegU regulon

The gene

Basic information

  • Locus tag: BSU35490

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transcription activator of degradative enzyme genes (sacB and degQ) and of comK expression
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated by DegS on Asp-56 PubMed, this modulates DNA-binding activity
  • Cofactor(s):
  • Effectors of protein activity: DNA-binding activity of DegU is inhibited by RapG PubMed
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced in the presence of ammonium (TnrA) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original Publications