Difference between revisions of "ComA"
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| + | = Categories containing this gene/protein = | ||
| + | {{SubtiWiki category|[[genetic competence]]}}, | ||
| + | {{SubtiWiki category|[[transcription factors and their control]]}}, | ||
| + | {{SubtiWiki category|[[quorum sensing]]}}, | ||
| + | {{SubtiWiki category|[[phosphoproteins]]}} | ||
=The protein= | =The protein= | ||
Revision as of 15:47, 30 November 2010
- Description: two-component system response regulator, controls gene expression in response to cell density (concentration of ComX)
| Gene name | comA |
| Synonyms | srfB, comAA |
| Essential | no |
| Product | two-component system response regulator |
| Function | regulation of genetic competence and quorum sensing |
| MW, pI | 23 kDa, 4.759 |
| Gene length, protein length | 642 bp, 214 aa |
| Immediate neighbours | yuxO, comP |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU31680
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
Categories containing this gene/protein
genetic competence, transcription factors and their control, quorum sensing, phosphoproteins
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ComA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: phosphorylated by ComP on an Asp residue
- Cofactor(s):
- Effectors of protein activity: phosphorylation activates DNA binding, DNA-binding activity of ComA is inhibited by RapC PubMed, RapD PubMed, RapF PubMed, RapH PubMed and RapK PubMed
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 1U83
- UniProt: P14204
- KEGG entry: [3]
- E.C. number: 4.4.1.19
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Daniel López, Roberto Kolter
Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis.
FEMS Microbiol Rev: 2010, 34(2);134-49
[PubMed:20030732]
[WorldCat.org]
[DOI]
(I p)
Leendert W Hamoen, Gerard Venema, Oscar P Kuipers
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading): 2003, 149(Pt 1);9-17
[PubMed:12576575]
[WorldCat.org]
[DOI]
(P p)
Original Publications
