comX

comX
168

competence pheromone precursor, transfers cell density signal to ComP; triggers the production of surfactin

Locus
BSU_31700
Molecular weight
6.38 kDa
Isoelectric point
4.36
Protein length
55 aaSequenceBlast
Gene length
168 bpSequenceBlast
Function
Quorum sensing
Product
competence pheromone precursor
Essential
no
Synonyms
comX
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist

Genomic Context

List of homologs in different organisms

This gene is a member of the following regulons

SigA regulon

Gene
Coordinates
3,255,853  3,256,020
Phenotypes of a mutant
the mutation suppresses the mucoid phenotype of ''motA or motB'' mutants due to loss of DegU phosphorylation and concomitant reduced expression of the ''capB-capC-capA-capE'' operon PubMed
defective in biofilm formation and sporulation PubMed
The protein
Structure
P45453 (AlphaFold)
Modification
is synthesized as an inactive precursor, cleaved, and modified (prenylated) on W53 by ComQ prior to excretion PubMed
ComX is degraded by Subtilisin PubMed
Localization
secreted (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
comQ-comX-comP-comA-yuxO
Description
PubMed
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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comQ→yuxO

2025-03-10 15:46:45

Jstuelk

110

150fea5ac7a55e0a32a0fafb306d0c860c9a2be7

E73017881E40042997BB444071E259402A0F5D1F

Biological materials
Mutant
BKE31700 (comX::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AATTAGGTCTTGCATCTTGT,  downstream forward: _UP4_GGTGATTAATAGGTGGATTA
BKK31700 (comX::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AATTAGGTCTTGCATCTTGT,  downstream forward: _UP4_GGTGATTAATAGGTGGATTA
References
Reviews
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Original Publications
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60D6EB02923D9ADE88F61A8CBBD882BA8BDD457E

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Time of last update: 2025-03-12 13:44:26

Author of last update: Jstuelk