GltB

• Description: small subunit of glutamate synthase, large subunit is gltA, glutamate biosynthesis is induced by sugar and repressed by arginine
  
  

Gene name	gltB
Synonyms
Essential	no
Product	glutamate synthase (small subunit)
Function	glutamate biosynthesis
MW, pI	54.6 kDa, 7.69
Gene length, protein length	1479 bp, 493 amino acids
Immediate neighbours	gltA, yogA
Gene sequence (+200bp)	Protein sequence
Genetic context File:GenE context.gif

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry:[2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2 L-glutamate + NADP(+) <=> L-glutamine + 2-oxoglutarate + NADPH

• Protein family: [3]

• Paralogous protein(s): none

Extended information on the protein

• Kinetic information:

• Domains:
  • nucleotide binding domain (NADP) (299–313)

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• Swiss prot entry: [4]

• KEGG entry: [5]

• E.C. number: [6]

Expression and regulation

• Operon: gltA gltB

• Sigma factor: SigA

• Regulation: induced by sugar, repressed by arginine (both mediated by GltC), repressed in the absence of ammonium (mediated by TnrA), pos. regulated by GltR

• Regulatory mechanism: activator: GltC; repressor: TnrA

• Additional information:

Labs working on this gene/protein

Linc Sonenshein, Tufts University, Boston, MA, USA Homepage

Jörg Stülke, University of Göttingen, Germany Homepage

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed