Phosphorelay

Parent categories	4. Lifestyles 4.2. Sporulation and Germination
Neighbouring categories	4.2.1. Sporulation proteins 4.2.2. Phosphorelay 4.2.3. Sporulation/ other 4.2.4. Germination
Related categories	two-component systems response regulator aspartate phosphatases phosphoproteins protein kinases and phosphatases
Overview on the categories (Excel file) All genes and their categories (Excel file)

Parent categories	3. Information processing 3.4. Regulation of gene expression
Neighbouring categories	3.4.1. Sigma factors and their control 3.4.2. Transcription factors and their control 3.4.3. Trigger enzymes 3.4.4. RNA binding regulators 3.4.5. Regulators of core metabolism 3.4.6. Transition state regulators 3.4.7. Phosphorelay 3.4.8. Quorum sensing 3.4.9. Other regulators
Related categories	see Table to the right
Overview on the categories (Excel file) All genes and their categories (Excel file)

The phosphorelay is a complex variation of a two-component regulatory system. It includes phosphotransferases that transfer the phosphoryl group from the sensor kinases to the ultimate target. The sporulation initiation phosphorelay is the paradigm of this class of signal transduction systems.

The kinases

• KinA (controlled by Sda, SivA, BslA, KipI, and KipA)
• KinB (controlled by Sda, KbaA, and KapB)
• KinC
• KinD
• KinE

Proteins controlliing the activity of the kinases

• BslA
• KapB
• KbaA
• KipA
• KipI
• Sda
• SivA
• SivC

The phosphotransferases

• Spo0F
• Spo0B

The ultimate target

• Spo0A

Phosphatases controlling the phosphorelay (and peptides that modulate their activity)

• Spo0E: dephosphorylation of Spo0A
• YisI: dephosphorylation of Spo0A
• YnzD: dephosphorylation of Spo0A
• RapA, PhrA: dephosphorylation of Spo0F
• RapB: dephosphorylation of Spo0F
• RapE, PhrE: dephosphorylation of Spo0F
• RapH: dephosphorylation of Spo0F
• RapP: dephosphorylation of Spo0F PubMed

Other protein controlling the activity of the phosphorelay

• the YmcA- YlbF-YaaT complex stimulates phosphotransfer to Spo0A PubMed

A mathematical model

Adaoha E C Ihekwaba, Ivan Mura, Gary C Barker
Computational modelling and analysis of the molecular network regulating sporulation initiation in Bacillus subtilis.
BMC Syst Biol: 2014, 8;119
[PubMed:25341802] [WorldCat.org] [DOI] (I e)

Sara Jabbari, John T Heap, John R King
Mathematical modelling of the sporulation-initiation network in Bacillus subtilis revealing the dual role of the putative quorum-sensing signal molecule PhrA.
Bull Math Biol: 2011, 73(1);181-211
[PubMed:20238180] [WorldCat.org] [DOI] (I p)