FabL

• Description: enoyl-acyl carrier protein reductase
  
  

Gene name	fabL
Synonyms	yfhR, ygaA
Essential	no
Product	enoyl-acyl carrier protein reductase
Function	fatty acid biosynthesis
Gene expression levels in SubtiExpress: fabL
Metabolic function and regulation of this protein in SubtiPathways: fabL
MW, pI	27 kDa, 5.967
Gene length, protein length	750 bp, 250 aa
Immediate neighbours	yfhS, sspE
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of lipids, sporulation proteins

This gene is a member of the following regulons

SigG regulon, SpoVT regulon, YfhP regulon

The gene

Basic information

• Locus tag: BSU08650

Database entries

• BsubCyc: BSU08650

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): FabI, one of the two proteins has to be present for viability PubMed

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU08650

• Structure: 3OIC PubMed

• UniProt: P71079

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • mutY-fabL-sspE PubMed
  • fabL-sspE PubMed

• Expression browser: fabL PubMed

• Sigma factor: SigA PubMed, SigG PubMed

• Regulation:
  • repressed by YfhP during exponential growth PubMed
  • repressed by SpoVT during forespore expression PubMed

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 206 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 750 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, exponential phase): 1540 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, early stationary phase after glucose exhaustion): 1009 PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium, late stationary phase after glucose exhaustion): 1634 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)

Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903] [WorldCat.org] [DOI] (P p)